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Phenotype Image Detail
Image
Caption (B) Image of an Atg4bGt(A029E06)Wrst/Atg4bGt(A029E06)Wrst (Atg4b-/-) mouse affected by head tilting (top right) and a wild-type (WT) mouse (top left). Insets show the angle of the head. As compared with WT mice (bottom left), mutant mice were unable to swim or float in the forced swim test (bottom right). (C) Light (top) and scanning (bottom) electron microscopy analyses of WT and mutant inner ears. Representative images show either the absence of otoconial crystals in the utricle of mutant mice (right) or the presence of abnormal otoconia that are oversized, less numerous, loose, and occasionally fused (middle), as compared with WT otoconia (left). The blur in the image is due to electrical interference. Scale bars: 50 um (top), 10 um (bottom).
Copyright This image is from Marino G, J Clin Invest 2010 Jul 1;120(7):2331-44 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:163712
Associated
Alleles
Symbol Name
Atg4bGt(A029E06)Wrst autophagy related 4B, cysteine peptidase; gene trap A029E06, German Gene Trap Consortium
Associated
Genotypes
Allelic Composition Genetic Background
Atg4bGt(A029E06)Wrst/Atg4bGt(A029E06)Wrst involves: 129S2/SvPas * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory