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| Caption | Hypoplastic and glomerulocystic kidneys in Arhgap35m1Bchd/Arhgap35m1Bchd (Arhgap35-/-) mutants. (D-E) Whole urogenital systems dissected at E17.5. In contrast to normal sized kidneys in control animals (panel D), Arhgap35m1Bchd/Arhgap35m1Bchd (E) kidneys exhibit hypoplasia (arrows) or agenesis (arrowheads). (J-K) Hematoxylin and Eosin stained sections (20X) show large glomerular cysts (asterisks), accompanied by occasional proximal tubule (PT) dilation in the mutant animals (K). (J'-K') Higher magnification (63x) images show that glomerular architecture is largely preserved in cystic glomeruli. Scale bars, 20um . *p<0.05, **p<0.01, ***p<0.005, ****p<0.001 (one-way ANOVA). | ||||
| Copyright | This image is from Stewart K, PLoS Genet 2016 Feb;12(2):e1005785, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:232342 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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