Phenotype Image Detail

Image

Caption

Hypoplastic and glomerulocystic kidneys in Arhgap35^tm1Jset/Arhgap35^m1Bchd (Arhgap35^-/D34). (F) Whole urogenital systems dissected at E17.5. Arhgap35^tm1Jset/Arhgap35^m1Bchd (F) kidneys exhibit hypoplasia (arrows) or agenesis (arrowheads). (L) Hematoxylin and Eosin stained sections (20x) show large glomerular cysts (asterisks), accompanied by occasional proximal tubule (PT) dilation in the mutant animals (L). (L') Higher magnification (63x) images show that glomerular architecture is largely preserved in cystic glomeruli. Scale bars, 20um . *p<0.05, **p<0.01, ***p<0.005, ****p<0.001 (one-way ANOVA).

This image is from Stewart K, PLoS Genet 2016 Feb;12(2):e1005785, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:232342

Associated
Alleles

Symbol	Name
Arhgap35^m1Bchd	Rho GTPase activating protein 35; mutation 1, Maxime Bouchard
Arhgap35^tm1Jset	Rho GTPase activating protein 35; targeted mutation 1, Jeffrey Settleman

Associated
Genotypes

Allelic Composition	Genetic Background
Arhgap35^m1Bchd/Arhgap35^tm1Jset	involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

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