Image |
|
||||||||
Caption | Bone tumorigenesis resulting from conditional heterozygous osteoblastic Prkar1a loss in Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 mice. (A) Full-body CT scan of a 33.6-week-old Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 mouse with bone tumors in the femur, spine, tail, and metatarsals (arrowheads). (D) H&E (left) and Masson's trichrome (right) staining of paraffin sections of a femur tumor from a 49.1-week-old Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 mouse. (F) TRAP histochemical stains of a 22.4-week-old Tg(Bglap2-TAg)1Rkho/0 (MOTO+) rib tumor (left), a 3.7-week-old Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 Tg(Bglap2-TAg)1Rkho/0 (Prkar1adeltaOB/+/MOTO+) tibia tumor (middle), and 49.1-week-old Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 femur tumor (right) show abundant osteoclasts. Scale bars: 150 um (D); 50 um (D, insets, and F). | ||||||||
Copyright | This image is from Molyneux SD, J Clin Invest 2010 Sep 1;120(9):3310-25 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:165282 | ||||||||
Associated Alleles |
|
||||||||
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/21/2024 MGI 6.24 |
![]() |
|