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| Caption | Age-related amyloid beta plaque progression in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 (rTg9191) mice. (A) A representative sagittal section of brain. Black rectangles indicate the regions of cerebral cortex and hippocampal formation in which amyloid beta plaques are shown in (B-E). (B-E) Representative photomicrographs showing age-dependent progression of amyloid beta plaques in female mice, visualized using 6E10 (B); 4G8, directed against a mid-region of amyloid beta (C); 139-5, an amyloid beta x-40-specific antibody (D); and 1-11-3, an amyloid beta x-42-specific antibody (E). Upper panels, cerebral cortex; lower panels, hippocampus. Scale bars: 100 um (upper panels), 200 um (lower panels). TTA, mice expressing only the tetracycline transactivator. (F) Quantification of 4G8-immunoreactive amyloid beta plaque load at various ages. | ||||||
| Copyright | This image is from Liu P, PLoS One 2015;10(5):e0126317, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:235351 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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