Phenotype Image Detail

Image

Caption

Vacuolization and broadened intercellular spaces present in Aldh3a2^{tm1b(EUCOMM)Wtsi}/Aldh3a2^{tm1b(EUCOMM)Wtsi} (-/-) epidermis. A, paraffin sections (4 um) of skin prepared from wild-type (WT) and mutant mice at P0 were subjected to H&E staining. Bright field images were photographed under a DM5000B light microscope. Arrows indicate vacuolization. Bar, 20 um. B and C, skin sections of WT and mutant mice at P0 were subjected to electron microscopy. Arrows indicate broadened intercellular spaces. Bar, 3 um (B), 1 um (C). SC, stratum corneum; SG, stratum granulosum; SS, stratum spinosum; SB, stratum basale; De, dermis.

This image is from Naganuma T, J Biol Chem 2016 May 27;291(22):11676-88 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:234695

Associated
Alleles

Symbol	Name
Aldh3a2^{tm1b(EUCOMM)Wtsi}	aldehyde dehydrogenase family 3, subfamily A2; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated
Genotypes

Allelic Composition	Genetic Background
Aldh3a2^{tm1b(EUCOMM)Wtsi}/Aldh3a2^{tm1b(EUCOMM)Wtsi}	involves: C57BL * C57BL/6J * C57BL/6N * DBA

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24