Phenotype Image Detail

Image

Caption

Vacuolization and broadened intercellular spaces present in Aldh3a2^{tm1b(EUCOMM)Wtsi}/Aldh3a2^{tm1b(EUCOMM)Wtsi} (-/-) epidermis. A, paraffin sections (4 um) of skin prepared from wild-type (WT) and mutant mice at P0 were subjected to H&E staining. Bright field images were photographed under a DM5000B light microscope. Arrows indicate vacuolization. Bar, 20 um. B and C, skin sections of WT and mutant mice at P0 were subjected to electron microscopy. Arrows indicate broadened intercellular spaces. Bar, 3 um (B), 1 um (C). SC, stratum corneum; SG, stratum granulosum; SS, stratum spinosum; SB, stratum basale; De, dermis.

This image is from Naganuma T, J Biol Chem 2016 May 27;291(22):11676-88 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:234695

Associated
Alleles

Symbol	Name
Aldh3a2^{tm1b(EUCOMM)Wtsi}	aldehyde dehydrogenase family 3, subfamily A2; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated
Genotypes

Allelic Composition	Genetic Background
Aldh3a2^{tm1b(EUCOMM)Wtsi}/Aldh3a2^{tm1b(EUCOMM)Wtsi}	involves: C57BL * C57BL/6J * C57BL/6N * DBA

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