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Phenotype Image Detail
Image
Caption H&E staining of decidua containing embryos did not reveal morphological abnormalities between wild-type (wt) and heterozygous Gpx4tm4Marc mutant (wt/ser) embryos. In Gpx4tm4Marc/Gpx4tm4Marc (ser/ser) embryos, however, intrauterine resorptions of embryonic tissue were evident. Moreover, a clear distinction of the embryonic part in the three germinal layers was not unequivocally possible in contrast to heterozygous and wild-type embryos. Am, amnion; CH, chorion; EC, ectoderm; EM, embryonic tissue; EN, endoderm; EX, extraembryonic tissue; ME, mesoderm. Scale bars: white, 100 um; black, 50 um).
Copyright This image is from Ingold I, J Biol Chem 2015 Jun 5;290(23):14668-78 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:225651
Associated
Alleles
Symbol Name
Gpx4tm4Marc glutathione peroxidase 4; targeted mutation 4, Marcus Conrad
Associated
Genotypes
Allelic Composition Genetic Background
Gpx4tm4Marc/Gpx4tm4Marc involves: 129S6/SvEvTac * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory