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| Caption | Progressive loss of cone photoreceptors in Guca1atm1.1Hunt/Guca1a+ and Guca1atm1.1Hunt/Guca1atm1.1Hunt mice, Representative retinal flat mounts taken from 5 month-old mice stained with PNA and anti-cone opsin antibody. There are fewer PNA-positive cone cells present in mutant compared to wild-type (WT) retinae, as well as a fewer opsin-expressing cells in mutant versus WT retinae. Quantitative analysis shows that there are significantly fewer cone ops in expressing cells in mutant retinae than PNA-positive cells, although the labelling of both markers is significantly reduced in heterozygous and homozygous mutant mice as compared to WT littermates. (b) Representative retinal flatmounts taken from 12 month-old mice confirms progression of cone degeneration; in mutant mice, there are fewer opsin-positive cells at 12 months compared to WT littermates. | ||||||
| Copyright | This image is from Buch PK, PLoS One 2011;6(3):e18089, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171667 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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