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| Caption | Liver phenotype. (A) Representative liver sections of 6-month-old wild-type (WT), Stab1tm1.1Cger/Stab1tm1.1Cger (stab-1), Stab2tm1.1Cger/Stab2tm1.1Cger (stab-2), and Stab1tm1.1Cger/Stab1tm1.1Cger Stab2tm1.1Cger/Stab2tm1.1Cger (stab-dko) mice of C57BL/6 genetic background were stained with Sirius red to identify the degree of fibrosis (n = 5). No Sirius red-positive fibers except around large blood vessels were detected in WT specimens, whereas few positive fibers were seen in either homozygous mutant specimens. Sirius red staining of stab-dko livers identified fibrotic fibers along the sinusoidal network. Original magnification, 100. Scale bars: 100 um. (B) Representative transmission electron microscopy (EM) images of liver sinusoids captured from 6-month-old WT as well as stab-dko mice. Collagen fibers in the space of Disse close to the sinusoidal lumen are indicated by arrows. H, hepatocyte; SL, sinusoidal lumen. n = 3. Original magnification, 10,000. Scale bar: 10 um. | ||||||
| Copyright | This image is from Schledzewski K, J Clin Invest 2011 Feb 1;121(2):703-14 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171818 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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