Phenotype Image Detail

Image

Caption

Kidney phenotype. (A) Representative PAS-stained kidney sections from 3-month-old WT, Stab1^tm1.1Cger/Stab1^tm1.1Cger (stab-1), Stab2^tm1.1Cger/Stab2^tm1.1Cger (stab-2), and Stab1^tm1.1Cger/Stab1^tm1.1Cger Stab2^tm1.1Cger/Stab2^tm1.1Cger (stab-dko) mice of Balb/c genetic background. The glomeruli from WT as well as single homozygous mutant mice had a normal appearance. In contrast, mesangial expansion was evident in stab-dko mice (arrows) (n = 3). Original magnification, 400. Scale bars: 20 um. (B) Representative kidney sections of 3-month-old WT and stab-dko mice of C57BL/6 background were stained with Sirius red to identify the degree of fibrosis (n = 3). Strong Sirius red-positive staining indicating collagen deposition was detected only in stab-dko glomeruli. The extent of the glomerulosclerosis was similar in stab-dko mice of both Balb/c and C57BL/6 genetic background (not shown). Original magnification, 200. Scale bars: 50 um. (C) Representative transmission electron microscopy (EM) images of 4-week-old stab-dko glomeruli of Balb/c genetic background as compared with WT showed large deposits of fibrillar material (red arrows) and a severely enlarged mesangium (M) with narrowing of capillary lumens (C), partial loss of foot processes (FP) and regular basement membrane (BM). n = 3. Original magnification, 10,000. Scale bars: 10 um.

This image is from Schledzewski K, J Clin Invest 2011 Feb 1;121(2):703-14 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171818

Associated
Alleles

Symbol	Name
Stab1^tm1.1Cger	stabilin 1; targeted mutation 1.1 Cyrill Geraud
Stab2^tm1.1Cger	stabilin 2; targeted mutation 1.1, Cyrill Geraud

Associated
Genotypes

Allelic Composition	Genetic Background
Stab1^tm1.1Cger/Stab1^tm1.1Cger Stab2^tm1.1Cger/Stab2^tm1.1Cger	B6.129S2-Stab2^tm1.1Cger Stab1^tm1.1Cger
Stab1^tm1.1Cger/Stab1^tm1.1Cger Stab2^tm1.1Cger/Stab2^tm1.1Cger	C.129S2-Stab2^tm1.1Cger Stab1^tm1.1Cger

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24