About   Help   FAQ
Phenotype Image Detail
Image
Caption (A) Splenomegaly was observed in both Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ (left: ROSA26.vFLIP;CD19.cre mice Tg) and Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Ighg1tm1(cre)Cgn/Ighg1+ mice (right: ROSA26.vFLIP;Cgamma1.cre mice Tg); at least 20 Tg and control anaimals were analyzed (error bars indicate SEM). (B) H&E, PNA, and BCL6 staining revealed the lack of germinal centers (GCs) in both Tg mouse lines. Abortive GCs in Peyer patches of Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Ighg1tm1(cre)Cgn/Ighg1+ mice are shown (arrows). Scale bars: 200 um.
Copyright This image is from Ballon G, J Clin Invest 2011 Mar 1;121(3):1141-53 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172031
Associated
Alleles
Symbol Name
Cd19tm1(cre)Cgn CD19 antigen; targeted mutation 1, University of Cologne
Gt(ROSA)26Sortm1(gp80,EGFP)Eces gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ethel Cesarman
Ighg1tm1(cre)Cgn immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, University of Cologne
Associated
Genotypes
Allelic Composition Genetic Background
Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+ 		either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+ 		either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory