Phenotype Image Detail

Image

Caption

3 (D-G) Morphology of two-week-old (P14) unskinned mouse heads (D), brains (E, F), and cerebellums (G), for wild-type (WT) and Cep120^tm1.2Blnw/Cep120^tm1.1Blnw Tg(Nes-cre)1Atp/0 (Cep120^-/fl;nes-cre) mice. The lines are in the same length for both WT and mutant, thus indicating the relative brain size or the extent of hydrocephalus in the mutant. Hematoxylin and eosin (H&E) staining of sagittal brain sections (E) confirms that the mutant ventricles of the brain are severely dilated. The boxed area in F is enlarged in (G). Cerebellums are outlined. The mutant cerebellum is significantly smaller (F).

This image is from Wu C, PLoS One 2014;9(9):e107943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:220629

Associated
Alleles

Symbol	Name
Cep120^tm1.1Blnw	centrosomal protein 120; targeted mutation 1.1, Baolin Wang
Cep120^tm1.2Blnw	centrosomal protein 120; targeted mutation 1.2, Baolin Wang
Tg(Nes-cre)1Atp	transgene insertion 1, Andreas Trumpp

Associated
Genotypes

Allelic Composition	Genetic Background
Cep120^tm1.1Blnw/Cep120^tm1.2Blnw Tg(Nes-cre)1Atp/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24