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Phenotype Image Detail
Image
Caption (a, b) Photographs of Bicd2tm1.1Hgrd/Bicd2tm1.1Hgrd (Bicd2-/-) mice showing a normal gross appearance at embryonic day 19 (a) and a dome-shaped head indicative of hydrocephalus at post-natal day 20 (b). (d) Coronal brain sections of P20 mice stained for LacZ and neutral red reveal enlarged lateral ventricles (LV), thinning of the cortex (Cx) and atrophy of several telencephalic areas including striatum (Str) and lateral septum (LS) in homozygote mutant mice and no change in heterozygote mutant mice. Note the moderate and high level of LacZ staining throughout the forebrain of heterozygous and homozygous mice, respectively, indicative of widespread BICD2 expression.
Copyright This image is from Jaarsma D, Nat Commun 2014;5():3411, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210236
Associated
Alleles
Symbol Name
Bicd2tm1.1Hgrd BICD cargo adaptor 2; targeted mutation 1.1, Casper Hoogenraad
Associated
Genotypes
Allelic Composition Genetic Background
Bicd2tm1.1Hgrd/Bicd2tm1.1Hgrd involves: C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory