Phenotype Image Detail

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Phenotype Image Detail

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Caption

a) Hair phenotype of mice expressing the knock-in construct. Heterozygous mice carrying one wild-type and one knock-in Ctsl^tm1.2Thre allele (Ctsl^{KiTTCdeltaSTOP}/wt) show no aberrations in normal coat. Photo of littermates taken at P30 shows Ctsl^tm1.2Thre/Ctsl^tm1.2Thre (Ctsl^{KiTTCdeltaSTOP}/Ctsl^{KiTTCdeltaSTOP}) mice fully resemble the periodical hair loss due to cathepsin L deficiency, while heterozygous mice show no aberrations.

This image is from Tholen M, Nat Commun 2014;5():4931, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:216506

Associated
Alleles

Symbol	Name
Ctsl^tm1.2Thre	cathepsin L; targeted mutation 1.1, Thomas Reinheckel

Associated
Genotypes

Allelic Composition	Genetic Background
Ctsl^tm1.2Thre/Ctsl^tm1.2Thre	involves: C57BL/6 * C57BL/6N

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