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| Caption | A) A comparison of newborn (P1) wild-type, Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi Rhbdf2tm1Mak/Rhbdf2tm1Mak (iR1/2-/-), Adam17tm1.1Bbl/Adam17tm1.1Bbl (Adam17-/-), Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi (iR1-/-), or Rhbdf2tm1Mak/Rhbdf2tm1Mak (iR2-/-) mice, which appeared similar except for the open eyes at birth (OEB) in Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi Rhbdf2tm1Mak/Rhbdf2tm1Mak and Adam17tm1.1Bbl Adam17tm1.1Bbl mice (arrows). (B and C) The OEB phenotype (arrows) is shown on macroscopic images of the head (B) and histological sections (C). (D) Aortic valve sections (arrows). (E) Sections through the femoral growth plate (the thickness of the hypertrophic zone is indicated by yellow lines). In all cases, the defects observed in double knockout mice (OEB, enlarged aortic valve, thickened zone of hypertrophic chondrocytes) closely resembled those in Adam17tm1.1Bbl/Adam17tm1.1Bbl mice, whereas Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi and Rhbdf2tm1Mak/Rhbdf2tm1Mak mice appeared normal. | ||||||||
| Copyright | This image is from Li X, Proc Natl Acad Sci U S A 2015 May 12;112(19):6080-5. Copyright 2015 National Academy of Sciences, U.S.A. J:221411 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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