Phenotype Image Detail

Image

Caption

(A, B) A genetic complementation test demonstrates that Map3k4 resides in the Thp deletion of proximal mouse Chromosome 17. XY embryos doubly heterozygous for Map3k4^byg and Del(17)T^hp (XY Thp/+, byg/+), on the C3H/HeH background, exhibit a range of defects of gonad development similar to Map3k4^byg homozygotes, including testes with regions lacking clear cord morphology (bracket, A) and XY gonads with an overt ovarian appearance that lack Sox9 transcription (right-hand side gonad, A). Sex-reversed XY gonads express Wnt4, a marker of ovary development (central gonad, B), in contrast to XY controls.

This image is from Bogani D, PLoS Biol 2009 Sep;7(9):e1000196, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:153050

Associated
Alleles

Symbol	Name
Del(17)T^hp	deletion, Chr 17, T, hairpin tail
Map3k4^byg	mitogen-activated protein kinase kinase kinase 4; boygirl

Associated
Genotypes

Allelic Composition	Genetic Background
Del(17)T^hp/Map3k4^byg	involves: AKR/J * C3H/HeH * C57BL/6J

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