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Caption | (A, B) A genetic complementation test demonstrates that Map3k4 resides in the Thp deletion of proximal mouse Chromosome 17. XY embryos doubly heterozygous for Map3k4byg and Del(17)Thp (XY Thp/+, byg/+), on the C3H/HeH background, exhibit a range of defects of gonad development similar to Map3k4byg homozygotes, including testes with regions lacking clear cord morphology (bracket, A) and XY gonads with an overt ovarian appearance that lack Sox9 transcription (right-hand side gonad, A). Sex-reversed XY gonads express Wnt4, a marker of ovary development (central gonad, B), in contrast to XY controls. | ||||||
Copyright | This image is from Bogani D, PLoS Biol 2009 Sep;7(9):e1000196, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:153050 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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