Phenotype Image Detail

Image

Caption

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2^tm1Dlo/Bcl2^tm1Dlo mice. (A) Kidney histology illustrates the dramatic polycystic disease in Bcl2^tm1Dlo/Bcl2^tm1Dlo (Bcl-2^-/-Bim^+/+) mice and its prevention by deletion of a single Bcl2l11 (Bim) allele or subtle mutations in Bcl2l11.(Bim^P/P = Bcl2l11^tm3.1Boui/Bcl2l11^tm3.1Boui; Bim^B/B = Bcl2l11^tm1.1Boui/Bcl2l11^tm1.1Boui; Bim^B/N = Bcl2l11^tm1.1Boui/Bcl2l11^tm2.1Boui; Bim^N/N = Bcl2l11^tm2.1Boui/Bcl2l11^tm2.1Boui). (B) Spleens of mice show that BH3 replacements in Bcl2l11 significantly restore the structure and size of the spleen in Bcl2-deficient animals. Bars, 1 mm.

This image is from Merino D, J Cell Biol 2009 Aug 10;186(3):355-62, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:153846

Associated
Alleles

Symbol	Name
Bcl2l11^tm1.1Boui	BCL2 like 11; targeted mutation 1.1, Philippe Bouillet
Bcl2l11^tm2.1Boui	BCL2 like 11; targeted mutation 2.1, Philippe Bouillet
Bcl2l11^tm3.1Boui	BCL2 like 11; targeted mutation 3.1, Philippe Bouillet
Bcl2^tm1Dlo	B cell leukemia/lymphoma 2; targeted mutation 1, Dennis Y Loh

Associated
Genotypes

Allelic Composition	Genetic Background
Bcl2^tm1Dlo/Bcl2^tm1Dlo	B6.129P2-Bcl2^tm1Dlo
Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Boui/Bcl2l11^tm1.1Boui	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm1.1Boui
Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm2.1Boui/Bcl2l11^tm2.1Boui	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm2.1Boui
Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm3.1Boui/Bcl2l11^tm3.1Boui	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm3.1Boui
Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Boui/Bcl2l11^tm2.1Boui	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm1.1Boui/Bcl2l11^tm2.1Boui

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