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| Caption | Pharyngeal arch artery (PAA) patterning defects in Chd7Whi/Chd7+ (Whi/+), Chd7Gt(XK403)Byg/Chd7+ (Chd7+/xk) and Chd7Gt(XK403)Byg/Chd7+ Tbx1tm1Bld/Tbx1+ (Chd7+/xk;Tbx1+/-) embryos. Black arrows denote absent fourth PAA; red arrowheads denote absence of arches; dashed lines denote thymic lobes (t). pa1, pharyngeal arch 1; III, third PAA; IV, fourth PAA; VI, sixth PAA; rc, right common carotid; lc, left common carotid; rs, right subclavian; ls, left subclavian; ao, aortic arch; h, heart; pt, pulmonary trunk; da, ductus arteriosus. (A-H) Ink-injected PAAs at E10.5. (A and B) Right and left lateral views of ink-filled wild-type (WT) PAAs after intracardiac ink injection. (C and D) Chd7Whi/Chd7+ (Whi/+) embryos with absence of the fourth PAA (black arrows). (E-H) Chd7+/xk embryos with absent fourth PAA. (I-P) Great vessels in WT (I), Chd7+/xk (J-M), and Chd7+/xk;Tbx1+/- (N-P) embryos at E14.5. (J) Type B interruption of the aortic arch (IAA-B) with a right-sided pulmonary trunk. (K) Cervical aortic arch and hypoplastic, ectopic thymic lobes. (L) Absent right subclavian artery (ARS) with hypoplastic right thymic lobe and left lobe removed to examine the aortic arch. (M) ARS. (N) Right brachiocephalic and cervical right subclavian overlying the right thymic lobe, as well as hypoplastic, irregular, and ectopic thymic lobes. (O) IAA-B and ARS. (P) IAA-B, right brachiocephalic artery overlying right thymic lobe, and cervical right subclavian, as well as hypoplastic, irregular, and ectopic thymic lobes. (Q) WT thymic lobes. (R) Chd7+/xk embryo with irregularly shaped thymic lobes. (S and T) Foxn1 in situ hybridization marking the E10.5 thymic primordium. (S) WT Foxn1 expression in the third pharyngeal pouch. (T) Chd7+/xk embryo. White arrow indicates absent Foxn1 expression. Scale bars: 100 um (A-H, S, and T); 1 mm (I-R). | ||||||||
| Copyright | This image is from Randall V, J Clin Invest 2009 Nov;119(11):3301-10 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154590 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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