Phenotype Image Detail

Image

Caption

Macroscopic analyses of the Metaphyseal Chondrodysplasia Type Schmid phenotype in Col10a1^tm1.1Rpbh/Col10a1^tm1.1Rpbh mice. (A) Skeletal preps of new born mice stained with alizarin red (bone) and alcian blue (cartilage). (B) Growth curves of mice (females) Col10a1^tm1.1Rpbh/Col10a1⁺ heterozygous (wt/m) and homozygous Col10a1^tm1.1Rpbh/Col10a1^tm1.1Rpbh (m/m) for for the p.Asn617Lys mutation, compared to wild-type (wt/wt) littermates. (C) X-ray images of male mice at 11 weeks of age, scale bar = 1 cm. (D) Comparison of bone lengths between wild-type and homozygous mutant mice: (i) pelvis; (ii) femur, vertical white scale bar = 1 cm.

This image is from Rajpar MH, PLoS Genet 2009 Oct;5(10):e1000691, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:154052

Associated
Alleles

Symbol	Name
Col10a1^tm1.1Rpbh	collagen, type X, alpha 1; targeted mutation 1.1, Raymond P Boot-Handford

Associated
Genotypes

Allelic Composition	Genetic Background
Col10a1^tm1.1Rpbh/Col10a1^tm1.1Rpbh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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