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| Caption | Lethality with hemorrhages in the lung and GI tract in Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ (mutant) mice. (A) Kaplan-Meier survival curve, showing lethality in mutant male and female adult mice. Female mice were more sensitive to Acvrl1 (Alk1) deletion than males. (B-D) Mutant mice displayed external signs of internal bleeding and anemia, such as pale paws (B), a low pO2 level (C), and darkened feces (D) by 8 days after tamoxifen (TM) injection. (E) Reduced hematocrit in the mutants 8 days after TM injection. Error bars in C and E indicate SD. (F-H) Superficial blood vessels in the small intestine of the mutant 8 day after TM injecting were visualized by latex dye. Formation of arteriovenous malformation (AVM) judged by the presence of latex dye in both arteries and veins was apparent in the areas of Peyer's patches (G). Scale bars: 4 mm (F); 2 mm (G and H). *P < 0.05; **P < 0.001. | ||||||
| Copyright | This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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