Phenotype Image Detail

Image

Caption

Forebrain overgrowth in Wdfy3^disc/Wdfy3^disc (disc/disc) mutants. (d) Dorsal views of whole-mount brains show morphological anomalies in the Wdfy3^disc/Wdfy3^disc mutants where indicated by the asterisk. (e) Nissl-stained coronal hemisections through the forebrains of E15.5 wild-type (WT) and mutants illustrate the malformations present in affected mutants. The green lines delineate the measurements taken for cortical length and thickness (D, dorsal; ML, mediolateral; L, lateral), while the orange area indicates how cortical size was measured. (f) Closeups of the mediolateral Cx illustrate cortical thinning in mutants.

This image is from Orosco LA, Nat Commun 2014;5():4692, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:225200

Associated
Alleles

Symbol	Name
Wdfy3^disc	WD repeat and FYVE domain containing 3; disconnected

Associated
Genotypes

Allelic Composition	Genetic Background
Wdfy3^disc/Wdfy3^disc	involves: C57BL/6J * FVB/NJ

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