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| Caption | Absence of proliferation during goblet cell hyperplasia in Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-Spdef)1Jaw/0 (Scgb1a1-rtTA/TRE2-Spdef) mice. The mutant mice were treated with doxycycline for 3 days. Wild-type (WT) mice were sensitized with ovalbumin. Cell proliferation was assayed by detection of BrdU uptake. BrdU was administered daily by i.p. injection during treatment with doxycycline and nasal sensitization with ovalbumin (day 24 through day 29). Goblet cell differentiation indicated by Alcian blue staining was induced in both models. Neither SPDEF nor ovalbumin sensitization increased phosphohistone H3 (pHH3) or BrdU staining in goblet cells. Intestinal tissue collected from the same animal receiving BrdU substrate served as a positive control for proliferation (lower panels). All scale bars: 25 um. | ||||||
| Copyright | This image is from Chen G, J Clin Invest 2009 Oct;119(10):2914-24 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154639 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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