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| Caption | Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain. (A) Dosage dependent rescue of the truncated tail phenotype of Lfngtm1Rjo/Lfngtm1Rjo;cLfng+ BBL E18.5 fetuses. Homozygous BBL-1 (Tg(Lfng*-LFNG)1Dihz/Tg(Lfng*-LFNG)1Dihz Lfngtm1Rjo/Lfngtm1Rjo) tails resemble those of hemizygous 5kL (Tg(Lfng-LFNG)1Dihz/0 Lfngtm1Rjo/Lfngtm1Rjo), and weak hemizygous BBL-2 (Tg(Lfng*-LFNG)2Dihz/0 Lfngtm1Rjo/Lfngtm1Rjo) resemble Lfngtm1Rjo/Lfngtm1Rjo (Lfng-/-) mice. White arrowheads point at the tip of the tails; scale bar, 5 mm; asterisk, midgut that failed to return to the reduced peritoneal cavity (found in 5/42 double mutant E18.5 fetuses). (B, C) E18.5 skeletons of 5kL embryos show regular vertebrae all along the length axis like WT [B, lateral (upper panel) and dorsal (lower panel) view] whereas Lfngtm1Rjo/Lfngtm1Rjo skeletons (C) exhibit regular vertebrae only in the sacral area. (D, E) BBL skeletons show a regional rescue in the tail area adjacent to the sacral area. The cervical, c; thoracic, t; lumbar, l; sacral, s; and tail regions of the vertebral columns are indicated, as are: ar, vertebral arch; bo, vertebral body; il, ilium. Regular sacral vertebrae in the bottom panels of (C) and (E), magnifications of the middle panels, are labelled with white asterisks. Note the cranial shift of the left side of sacral vertebrae in the Lfngtm1Rjo/Lfngtm1Rjo fetus (C bottom), indicative of homeotic transformation. Scale bar (bottom of D), 5 mm. (F) A schematic quantitative comparison of lengths of cervical/thoracic (c+t, green boxes), lumbar (l, yellow boxes), sacral (s, blue boxes), and tail (orange boxes) sections of vertebral columns of various genotypes indicates a dose dependent rescue of the tail length in BBL fetuses, but not of the length of the cervical + thoracic area. Boxes for each region are aligned to the left (cranial) end. (G) Skeleton preparations of adult mice (dorsal views) show the truncated tail but normal Lfngtm1Rjo/Lfngtm1Rjo sacral area (top), a partial tail rescue in hemizygous BBL-1 mice (middle) and an overall rescue in 5kL mice (bottom); scale bar, 10 mm. | ||||||||||||
| Copyright | This image is from Stauber M, PLoS One 2009;4(11):e7996, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155378 | ||||||||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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