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Phenotype Image Detail
Image
Caption Amyloid pathology and glial inflammation in Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mouse brain. B, Congo-red stained plaque core (red) in the frontal cortex of a Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0 (hemizygous) ARTE10 mouse at 5 months of age. The green bi-refringence in polarized light (inset) is diagnostic of amyloid. C, D, Thioflavin-S positive plaque cores (green), each encircled by a sphere (corona) of dilated, strongly ubiquitin-positive dystrophic neurites (red) in the subiculum of a Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte (homozygous) ARTE10 mouse at 3 months of age (D) and in the frontal cortex of a 19 months old hemizygous mouse (C), the latter with concomitant amyloid angiopathy (arrow). E, F, AT8-positive hyperphosphorylated tau (red) in dystrophic neurites adjacent to plaque cores (green: Ab40 and Ab42) in homozygous ARTE10 mice at 12 (E) and 8 (F) months of age.
Copyright This image is from Willuweit A, PLoS One 2009;4(11):e7931, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155410
Associated
Alleles
Symbol Name
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte transgene insertion 10, TaconicArtemis
Associated
Genotypes
Allelic Composition Genetic Background
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte involves: C57BL/6 * CBA
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0 involves: C57BL/6 * CBA

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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory