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Phenotype Image Detail
Image
Caption Aberrant cardiomyocyte oranization and contractility in Hnrnputm1.1Tman/Hnrnputm1.1Tman Tg(Ckmm-cre)5Khn/0 (Ckmm-KO) hearts. (A) Mutant hearts are dilated and display disorganized cardiomyocytes compared with controls. Shown is the H&E staining of P14 heart sections of both control and mutant hearts. A low-magnification view of the heart and high-magnification views of cardiomyocyte arrangements are shown. Trichrome staining of P14 heart sections and WGA & DAPI staining for P11 heart sections are also shown. (Black scale bar, 40 um; white scale bar in Far Right panels, 10 um.) (B) Abnormal actin dynamics and shortened sarcomere in mutant hearts. Heart sections (P11) were stained with phalloidin and antibodies against Desmin to reveal actin fiber and sarcomere Z line, respectively. (Scale bar, 10 um.) (C) Mutant cardiomyocytes have contractility defects. Control and mutant hearts (P11) were perfused under relaxing conditions; heart sections were prepared and examined by electron microscopy. Two green lines spanning 8.772 um were drawn in both control and mutant samples to compare the unit length of sarcomeres.
Copyright This image is from Ye J, Proc Natl Acad Sci U S A 2015 Jun 9;112(23):E3020-9. Copyright 2015 National Academy of Sciences, U.S.A. J:223139
Associated
Alleles
Symbol Name
Hnrnputm1.1Tman heterogeneous nuclear ribonucleoprotein U; targeted mutation 1.1, Tom Maniatis
Tg(Ckmm-cre)5Khn transgene insertion 5, C Ronald Kahn
Associated
Genotypes
Allelic Composition Genetic Background
Hnrnputm1.1Tman/Hnrnputm1.1Tman
Tg(Ckmm-cre)5Khn/0
involves: 129S4/SvJaeSor * FVB

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory