Phenotype Image Detail

Image

Caption

Resistance to LPS-induced lung injury in Nr1h3^tm1Wexi/Nr1h3^tm1Wexi mice. Wild-type (WT) and Nr1h3^tm1Wexi/Nr1h3^tm1Wexi (LXR-KI) mice recieved intranasal instillation of saline or LPS. The fifth group of WT mice was treated wtih GW3965 (GW, 20 mg/kg, daily, intraperitoneally) for 7 days before being teated with LPS. Hematoxylin and eosin staining of lung sections derived from mice treated with saline or LPS. Arrowheads indicate neutrophil infiltration (n = 6 for each group).

This image is from Gong H, J Biol Chem 2009 Oct 30;284(44):30113-21 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:155709

Associated
Alleles

Symbol	Name
Nr1h3^tm1Wexi	nuclear receptor subfamily 1, group H, member 3; targeted mutation 1, Wen Xie

Associated
Genotypes

Allelic Composition	Genetic Background
Nr1h3^tm1Wexi/Nr1h3^tm1Wexi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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