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Phenotype Image Detail
Image
Caption In wild-type (WT) mouse (B), there were many corpora lutea (black arrow) and follicles at different stages of growth. Healthy early antral follicles (gray arrow), healthy preovulatory follicles (dotted arrow), and atretic follicles (white arrow) are present. In the Esr2tm1.1Gust/Esr2tm1.1Gust (ER-Deltaex3) infertile mouse (C), there were many preantral follicles and a few early antral follicles (gray arrow). Most late antral follicles are atretic (white arrow). There was no corpus luteum. In conclusion, mutant mouse ovaries display more atretic follicles and less corpora lutea than WT mice. There was no significant difference in the number of developing follicles between the WT and the mutant mice.
Copyright This image is from Maneix L, Proc Natl Acad Sci U S A 2015 Apr 21;112(16):5135-40. Copyright 2015 National Academy of Sciences, U.S.A. J:220968
Associated
Alleles
Symbol Name
Esr2tm1.1Gust estrogen receptor 2 (beta); targeted mutation 1.1, Jan-Ake Gustafsson
Associated
Genotypes
Allelic Composition Genetic Background
Esr2tm1.1Gust/Esr2tm1.1Gust B6J.129X1(Cg)-Esr2tm1.1Gust

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory