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| Caption | Increased susceptibility to induced colitis in Nlrp6tm1Macha/Nlrp6tm1Macha mice. Wild-type (Nlrp6+/+) and Nlrp6tm1Macha/Nlrp6tm1Macha (Nlrp6-/-) mice were challenged with 3% dextran sodium sulfate (DSS) for 6 or 7 days followed by a 10 day period of regular drinking water. (C). Endoscopic analysis was made before necropsy to observe the tissue damage after 6 days of DSS treatment. Representative photographs of dissected wild-type and Nlrp6tm1Macha/Nlrp6tm1Macha mice at day 6 (D) and day 17 (H). The histological score was evaluated on serial colonic sections stained with H&E at day 6 (from nine wild-type and six mutant mice) (F). | ||||
| Copyright | This image is from Normand S, Proc Natl Acad Sci U S A 2011 Jun 7;108(23):9601-6. Copyright 2011 National Academy of Sciences, U.S.A. J:173352 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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