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| Caption | Dilated cardiomyopathy (DCM) in Dicer1tm1Smr/Dicer1tm1Smr Tg(Myh6-cre)2182Mds/0 hearts. (a) Gross morphology of P0 wild-type (WT, +/+) and Dicer1 mutant (-/-) hearts. (b) H&E staining of sagittal sections of P0 WT and mutant hearts. (c) Higher-magnification images from H&E stained left ventricular myocardium of P0 WT and mutant hearts. (d) Immunohistology of P0 WT and mutant hearts for cTnT (green). DAPI stains nuclei. (e) Higher-magnification images from cTnT immunohistology-stained left ventricular myocardium of P0 WT and mutant hearts. ( f) Confocal microscopic images of cultured neonatal cardiomyocytes from WT and mutant hearts stained for cardiac alpha-TM. (g) Electron microscopic analysis of ventricular myocardium of WT and mutant hearts. There is substantially less organized myofibril in mutant hearts. (h) Higher magnification of electron micrographies of WT and mutant myocardium to show disarrayed sarcomere in mutant hearts. (i) Quantitative measurement of sarcomere length in WT and mutant hearts. (j) TUNEL staining (green) detected increased apoptosis in the left atrium and ventricle of P2 mutant heart. Antibody against cTnT was used to label cardiomyocytes (red). DAPI stains nuclei (blue). (k) Increased apoptosis in the left ventricular wall of P2 mutant hearts as revealed by TUNEL staining. (l) Quantitative measurement of TUNEL positive cells in P2 WT and mutant hearts. | ||||||
| Copyright | This image is from Chen JF, Proc Natl Acad Sci U S A 2008 Feb 12;105(6):2111-6. Copyright 2008 National Academy of Sciences, U.S.A. J:131962 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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