Phenotype Image Detail

Image

Caption

Phenotype of Slc20a1^tm1Lbek/Slc20a1^tm1.2Lbek (neo/delta5) compound heterozygotes. (A) Morphological appearance of Slc20a1^tm1Lbek/Slc20a1^tm1.2Lbek E14.5 embryos (right), as compared to wild-type (+/+) littermates (left). Note the severe anemia and slight decrease in size. (B-C) H&E staining of E14.5 sagital sections from wild-type and mutant livers. The mutant liver shows disorganized parenchyme, reduced cellularity and pyknotic nuclei (white arrow). (D-E) H&E staining of E12.5 sections from wild-type and mutant livers showing no difference between the two genotypes. Bar, 100 mm. (F-G) Close examination of yolk sac membranes from wild-type and mutant E14.5 embryos demonstrate the presence of a highly developed vasculature (black arrows) characterized by a decrease in red blood cell number. (H-I) May Grunwald/Giemsa staining of peripheral blood smears from E14.5 wild-type and mutant littermates. Note the similar morphology of red blood cells, but the higher percentage of nucleated erythrocytes (black arrows).

This image is from Beck L, PLoS One 2010;5(2):e9148, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:157997

Associated
Alleles

Symbol	Name
Slc20a1^tm1.2Lbek	solute carrier family 20, member 1; targeted mutation 1.2, Laurent Beck
Slc20a1^tm1Lbek	solute carrier family 20, member 1; targeted mutation 1, Laurent Beck

Associated
Genotypes

Allelic Composition	Genetic Background
Slc20a1^tm1Lbek/Slc20a1^tm1.2Lbek	involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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