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Phenotype Image Detail
Image
Caption Increase of amyloid beta deposits and amyloid beta 40 in the hippocampus and cortex of Vps35Gt(RRK261)Byg/Vps35+ Tg(APPSWE)2576Kha/0 mice. (A) Increase of amyloid beta deposits in 6-month or older Tg(APPSWE)2576Kha/0 Vps35Gt(RRK261)Byg/Vps35+ (Tg2576+/-;Vps35+/m) brain as compared with that of Tg(APPSWE)2576Kha/0 (Tg2576+/-) brain by immunohistochemical staining analysis using anti-6E10 antibody.
Copyright This image is from Wen L, J Cell Biol 2011 Nov 28;195(5):765-79, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:178937
Associated
Alleles
Symbol Name
Tg(APPSWE)2576Kha transgene insertion 2576, Karen Hsiao Ashe
Vps35Gt(RRK261)Byg VPS35 retromer complex component; gene trap RRK261, BayGenomics
Associated
Genotypes
Allelic Composition Genetic Background
Vps35Gt(RRK261)Byg/Vps35+
Tg(APPSWE)2576Kha/0 		involves: 129P2/OlaHsd * C57BL/6 * SJL
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory