Phenotype Image Detail

Image

Caption

The Osr1^tm2.1Jian/Osr1^tm2.1Jian embryos die prenatally. A, B: A pair of Osr1^tm2.1Jian/Osr1⁺ (A) and Osr1^tm2.1Jian/Osr1^tm2.1Jian (B) embryos harvested at E12.0. Note the homozygous mutant embryo had dilated epicardium (arrow in B) and showed hemorrhaging in the trunk region. C-E: Heterozygous (C) and homozygous (D and E) embryos harvested at E14.5. The mutant embryo shown in (D) was dead and arrested development by E12.5 (arrowhead points to the forelimb bud, which shows a characteristic E12 limb morphology, in contrast to the well formed digits in the heterozygous littermate in C). The mutant embryo shown in E was alive but had generalized edema (arrow).

This image is from Lan Y, Genesis 2011 May;49(5):419-22, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:172133

Associated
Alleles

Symbol	Name
Osr1^tm2.1Jian	odd-skipped related transcription factor 1; targeted mutation 2.2, Rulang Jiang

Associated
Genotypes

Allelic Composition	Genetic Background
Osr1^tm2.1Jian/Osr1^tm2.1Jian	involves: 129S1/Sv * FVB/N

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