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| Caption | Mia3tm1Lex/Mia3tm1Lex (Mia3-/-) embryos are dwarfed, edemic, and fail to form a mineralized skeleton. (A and B) Mutant embryos display a shortening of the snout and limbs at 16.5 days post coitum (dpc). (C and D) Mutant embryos are significantly dwarfed at 18.5 dpc. (E and F) Alizarin red-positive skeletal mineralization initiates within the intramembranous bone of the jaw and endochondral bones of the clavicles of 13.5-dpc wild-type (WT) embryos (arrows) but is absent from the Alcian blue-positive cartilage anlagen of mutants. (G and H) Mineralization is advanced in nearly all axial and appendicular elements in 15.5-dpc control embryos but is profoundly delayed in the null skeleton. (I-L) Calcified matrix is apparent in the bones of 18.5-dpc knockout animals (I and J), but micro-CT (n = 3) maximum intensity projections highlight complete absence of the mature ossified skeleton (K and L). Bars, 1 mm. | ||||||
| Copyright | This image is from Wilson DG, J Cell Biol 2011 May 30;193(5):935-51, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:172737 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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