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| Caption | Morphological developmental abnormalities in Cyp51tm1.1Bfro/Cyp51tm1.1Bfro (-/-) embryos. A, The mutant embryos were first distinguished at E11.5-E12.5 by kinked and short tails (arrow). Nuchal translucence extending dorsolaterally from the nuchal region was observed in knock-out embryos from stage E12.5 to lethality that occurred at E15.0. At stage E15.5, all knock-out embryos were in an advanced stage of resorption (right most knock-out embryo). B, example of nuchal translucence with hemorrhages (arrow) at E14.5. C, variable phenotypes, ranging from mild to severe (left-right), of soft tissue syndactyly in the right hindlimb at E14.5. D, representative limb skeletal abnormalities demonstrated by Alcian blue dye staining. Micromelia (shortened limbs) was observed in all examined specimens. Radius and tibia were shortened and bowed (arrows). High magnification demonstrated signs of femuro-tibial synostosis (arrow). E, tarsal and carpal elements were underdeveloped and distal phalanges were absent. Joining of fingers or toes (syndactyly) was a prominent feature as well as post-axial polydactyly. Camptodactyly was most obvious in the left forelimb. FL, forelimb; HL, hindlimb (left/right). F, gross histological examination of embryos at E14.5. Extended subcutaneous, under-development of tongue, and absence of palatal shelf bone (arrow) was visible in knock-out embryos. G, the most prominent head abnormality, micrognathia, is shown in Alcian blue-stained specimens. Arrow points to the tongue in a wild-type embryo. The tongue did not develop normally in knock-out embryos. Scale bars indicate 1 mm. Wild-type, heterozygous, and knock-out embryos are designated +/+, +/-, and -/-, respectively. | ||||
| Copyright | This image is from Keber R, J Biol Chem 2011 Jun 25;(): and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:173366 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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