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| Caption | Spermiogenesis defect in Tdrd6tm1Chum/Tdrd6tm1Chum males. (R) Gross appearance of Tdrd6tm1Chum/Tdrd6+ and Tdrd6tm1Chum/Tdrd6tm1Chum testes at 2 months. (S-U) H&E-stained sections of heterozygous (S) and homozygous (T and U) testes at 2 months. The arrow indicates mature spermatozoa. In homozygous testes (T and U), elongating spermatids were observed, but were reduced in number and had aberrant nuclear morphologies (arrowheads). sc, spermatocytes, rs, round spermatids, es, elongating spermatids. (V and W) H&E-stained sections of heterozygous (V) and homozygous (W) epididymides at 2 months. The arrow indicates mature spermatozoa. (X and Y) TUNEL staining (red) of apoptotic cells in heterozygous (X) and homozygous (Y) testis sections counterstained with a Hoechst dye (blue). (AA and AB) Acrosome staining [peanut agglutinin (PNA), red] of heterozygous (AA) and homozygous (AB) spermatids counterstained with a Hoechst dye (blue). Mutant spermatids (AB) had elongating nuclei with acrosomes spreading over (steps 13-14 spermatids). (Scale bars: F-I, P, Q, and S-Y, 25 um; R, 1 mm; AA and AB, 10 um. | ||||
| Copyright | This image is from Tanaka T, Proc Natl Acad Sci U S A 2011 Jun 28;108(26):10579-84. Copyright 2011 National Academy of Sciences, U.S.A. J:173550 | ||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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