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| Caption | Slc39a5tm1Gka/Slc39a5tm1Gka Tg(Cela1-cre/ERT)1Lgdn/0 (Zip 5PancKO) mice exhibit increased sensitivity to zinc-induced acute pancreatitis. Two weeks after the last tamoxifen injection, control (Control) littermates and mutants (n = 5) were given an I.P. injection of zinc sulfate (12.5 mg zinc/kg body weight) and 48 hours later pancreata were harvested and paraffin sections were prepared and stained with hematoxylin and eosin (panels A-D) or stained for SLC39A5 using immunohistochemistry (panels E and F). Panels A and B represent control mice whereas panels C and D represent mutant mice. Dark brown deposits on the basolateral surfaces of acinar cells indicate positive staining. Black arrowheads in panel F demarcate large cytoplasmic vaculoles found in acinar cells of mutant mice in response to zinc. Panels A-D are photographed at 200X magnification and panels E and F are photographed at 1000X magnification. | ||||||
| Copyright | This image is from Geiser J, PLoS One 2013;8(11):e82149, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209760 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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