Phenotype Image Detail

Image

Caption

Representative photographs of adult hearts after tamoxifen inducible heart-specific Cre mediated Med1 deletion. It is evident that Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ (TmcsMed1^-/-) mouse heart is flaccid and flabby. Lower panel in (C) shows cross sections of Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ and the littermate control Med1^tm2Jkr/Med1^tm2Jkr (TmMed1^fl/fl) hearts stained with H&E.

This image is from Jia Y, PLoS One 2016;11(8):e0160755, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:243730

Associated
Alleles

Symbol	Name
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}	APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin
Med1^tm2Jkr	mediator complex subunit 1; targeted mutation 2, Janardan K Reddy

Associated
Genotypes

Allelic Composition	Genetic Background
Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129P2/OlaHsd * FVB/N

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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