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| Caption | Progressive degeneration of hair cells (HCs) in the organ of Corti of Marveld2tm1Sats/Marveld2tm1Sats (Tric-/-) mice. (a-f) Middle turn of the organ of Corti of wild-type (Tric+/+) (a-c) and homozygous mutant (d-f) mice on P12 (a,d), P14 (b,e) and P21 (c,f) stained with a HC marker myosin VIIa (green) and rhodamin phalloidin (red). IHCs (inner hair cells) (arrows) and OHCs (outer hair cells) (arrowheads) are regularly aligned in wild-type cochlea until P21 (a-c). Hair cells in mutant cochlea are normal on P12 (d). OHCs progressively degenerate at P14 (e) to P21 (f), and some IHCs degenerate at P21 (f). Scale bar = 10 um. Progressive loss of OHCs (g) and IHCs (h) from the cochlea of mutant mice. The loss of HCs is not detected in wild-type cochlea (blue lines). The degeneration of HCs of mutant mice (red lines) progresses during P12-P21 in OHCs (g) and P16-P60 in IHCs (h). | ||||
| Copyright | This image is from Kamitani T, Sci Rep 2015 Dec 18;5():18402, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:261357 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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