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| Caption | HSPB7 represses formation of abnormal actin bundles independent of Lmod2. (A) Immunofluorescence images of wild-type (WT), Lmod2tm1(KOMP)Vlcg/Lmod2tm1(KOMP)Vlcg (Lmod2 KO), Hspb7tm1.2Chen/Hspb7tm1.2Chen (HSPB7 KO), and Hspb7tm1.2Chen/Hspb7tm1.2Chen Lmod2tm1(KOMP)Vlcg/Lmod2tm1(KOMP)Vlcg (Lmod2/HSPB7 double KO; DKO) E10.5 heart sections stained with antibodies against HSPB7, Lmod2, and phalloidin (F actin.) (Scale bar: 100 mm.) (B) Representative immunofluorescence images (Left) and thin filament length measurements (Right) of control (Ctrl; including WT and Hspb7tm1.2Chen heterozygous mice), Lmod2 KO, HSPB7 KO, and Lmod2/HSPB7 DKO E10.5 embryos. Two embryos, 50-78 sarcomeres measured for each group. Error bars indicate mean SEM. Control, 0.849 0.0069 mm; Lmod2 KO, 0.77 0.0066 mm; HSPB7 KO, 0.885 0.0074 mm; DKO, 0.802 0.006 mm. Statistical significance was determined with one-way ANOVA. H, actin free H zone; Z, Z lines. **P < 0.01 (Ctrl vs. HSPB7 KO, P = 0.0033; Lmod2 KO vs. DKO, P = 0.0021); ****P < 0.0001. (Scale bar: 1 um.) (C) Representative immunofluorescence images of WT, Lmod2 KO, HSPB7 KO, and Lmod2/HSPB7 DKO E10.5 heart cryosections stained with antibodies against Tmod1, alpha-actinin (Actn2), and phalloidin (F actin). Abnormal actin bundles (AABs) are indicated by yellow arrowheads. (Scale bar: 10 mm.) | ||||||||
| Copyright | This image is from Wu T, Proc Natl Acad Sci U S A 2017 Nov 7;114(45):11956-11961. Copyright 2017 National Academy of Sciences, U.S.A. J:256653 | ||||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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