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| Caption | Absence of an endocardial/endothelial lineage in Etv2Gt(141.1H7)Cmhd/Etv2Gt(141.1H7)Cmhd heart and embryo. (Top) Morphological appearance of E8.5 wild-type (+/+, WT) and Etv2Gt(141.1H7)Cmhd/Etv2Gt(141.1H7)Cmhd (-/-) embryo littermates. Note that the whole-mount WT and null embryos are indistinguishable at E8.5. (Middle) Histological analyses of the WT and null embryo demonstrating an absence of the endocardial/endothelial lineage (End) and vasculature (PHV, primary heart vein; DA, dorsal aorta) in the null embryo compared to WT littermate. (Bottom) Immunohistochemical analysis of alpha-endomucin in the WT and null embryo further demonstrating an absence of the endocardial/endothelial lineage (arrowhead shown in WT) and an absence of the vasculature in the null embryo. A higher magnification field reveals an absence of endocardium in the null heart compared to the WT littermate (alpha-endomucin expressing endocardium indicated by an arrowhead). | ||||
| Copyright | This image is from Ferdous A, Proc Natl Acad Sci U S A 2009 Jan 20;106(3):814-9. Copyright 2009 National Academy of Sciences, U.S.A. J:143866 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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