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| Caption | LrgukKaos/LrgukKaos mice are oligoasthenoteratospermic and sterile. (D) PAS stained testis sections from wild-type (WT) and LrgukKaos/LrgukKaos (Kaos/Kaos) mice. * denotes the absence of sperm tails in the lumen of mutant males; black arrowheads point to fragmented acrosomes. Scale bar = 50 um. (E) Haematoxylin and eosin (H&E) stained sperm smears from WT and mutant animals. Scale bar = 10 um. (F) H&E staining of an epididymis from WT and mutant mice. The green arrow indicates sloughed of immature germ cells. Scale bar = 50 um. (G) Gamma-H2AX foci (green) were visible in retained step I-III elongated spermatids from mutant mice but not WT spermatids. Acrosomes were visualised by PNA (red) and nuclei were visualised with Dapi (blue). Scale bars = 10 um. *p<0.05, ****p<0.0001. | ||||
| Copyright | This image is from Liu Y, PLoS Genet 2015 Mar;11(3):e1005090, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:222840 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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