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Phenotype Image Detail
Image
Caption (H) Images of P12 kidneys from wild-type (WT) versus Trpm7tm1Clph/Trpm7tm1Clph Tg(Pax3-cre)1Joe/0 (upper) versus Trpm7tm1Clph/Trpm7tm1Clph Tg(Hoxb7-cre)5526Cmb/0 (lower) mice. Trpm7tm1Clph/Trpm7tm1Clph Tg(Pax3-cre)1Joe/0 mice have small pale kidneys. (I) Haematoxylin and eosin (H&E) staining of sections from P12 kidneys. The Trpm7tm1Clph/Trpm7tm1Clph Tg(Hoxb7-cre)5526Cmb/0 (HoxB7-Cre) kidney histology was normal, whereas the Trpm7tm1Clph/Trpm7tm1Clph Tg(Pax3-cre)1Joe/0 (Pax3-Cre) kidney contained cysts and a reduced number of glomeruli.
Copyright This image is from Jin J, Proc Natl Acad Sci U S A 2012 Jan 31;109(5):E225-33. Copyright 2012 National Academy of Sciences, U.S.A. J:181963
Associated
Alleles
Symbol Name
Tg(Pax3-cre)1Joe transgene insertion 1, Jonathan A Epstein
Trpm7tm1Clph transient receptor potential cation channel, subfamily M, member 7; targeted mutation 1, David E Clapham
Associated
Genotypes
Allelic Composition Genetic Background
Trpm7tm1Clph/Trpm7tm1Clph
Tg(Pax3-cre)1Joe/0 		involves: 129S4/SvJae * C57BL/6 * SJL
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory