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Phenotype Image Detail
Image
Caption Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0 (SKO) mice develop skin hyperpigmentation, but Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0 Trp53tm1Brn/Trp53tm1Brn (DKO) mice do not show skin hyperpigmentation. (C) Fontana-Masson staining of the paw skin. Melanin distribution in heterozygous control (Het) mice is mainly located in the dermis and less in the epidermis. In SKO mice, the epidermis becomes hyperplastic with increased melanin deposition. In DKO mice, the epidermis becomes dysplastic without melanin deposition. (Scale bars, 50 um.)
Copyright This image is from Chang CH, Proc Natl Acad Sci U S A 2017 Sep 19;114(38):E8035-E8044. Copyright 2017 National Academy of Sciences, U.S.A. J:253611
Associated
Alleles
Symbol Name
Csnk1a1tm1.1Ybn casein kinase 1, alpha 1; targeted mutation 1.1, Yinon Ben-Neriah
Tg(KRT14-cre/ERT)20Efu transgene insertion 20, Elaine Fuchs
Trp53tm1Brn transformation related protein 53; targeted mutation 1, Anton Berns
Associated
Genotypes
Allelic Composition Genetic Background
Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn
Tg(KRT14-cre/ERT)20Efu/0 		involves: 129S1/Sv * 129X1/SvJ * CD-1
Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre/ERT)20Efu/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory