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Phenotype Image Detail
Image
Caption Loss of Ube3b results in growth retardation. (A) Ube3btm1a(EUCOMM)Hmgu/Ube3btm1a(EUCOMM)Hmgu knockout (KO) mice show significant reduction in weight and length versus wild-type (WT) or heterozygous (Het) mice (weight: ***P<0.0001, two-way ANOVA; n = 5-18 WT, 7-37 Het, 5-12 KO; nose-to-rump length: ***P = 0.0003, one-way ANOVA; n = 9 WT, 10 Het, 9 KO).
Copyright This image is from Cheon S, Proc Natl Acad Sci U S A 2019 Feb 26;116(9):3662-3667. Copyright 2019 National Academy of Sciences, U.S.A. J:273879
Associated
Alleles
Symbol Name
Ube3btm1a(EUCOMM)Hmgu ubiquitin protein ligase E3B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Ube3btm1a(EUCOMM)Hmgu ubiquitin protein ligase E3B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Associated
Genotypes
Allelic Composition Genetic Background
Ube3btm1a(EUCOMM)Hmgu/Ube3btm1a(EUCOMM)Hmgu C57BL/6-Ube3btm1a(EUCOMM)Hmgu

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory