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| Caption | Phenotype of Grntm2.1Far/Grntm2.1Far (GrnR493X/R493X) mice recapitulates features of global knockout mice. (A) Mutant mice exhibit age-dependent microgliosis. Immunostaining of Iba1 in the thalamus. Arrowheads indicate selected Iba1+ cells. (C and D) Increased levels of total (C) and phosphorylated (D) TDP-43 in the cytoplasm of thalamic neurons of 12-month-old Grntm2.1Far/Grntm2.1Far and Grntm1.1Far/Grntm1.1Far (Grn-/-) mice. Arrowheads indicate cytoplasmic accumulation of TDP-43. (Scale bars, 20 um.) (E) Grntm2.1Far/Grntm2.1Far mice exhibit age-dependent reduction of synaptic density. (E) Immunostaining of synaptophysin in the thalamus of 13-month-old mice. (Scale bar, 10 um.) (G) Grntm2.1Far/Grntm2.1Far mutant mice have increased lipofuscin in the brain. (G) Images of autofluorescent lipofuscin (green channel) in the thalamus of 19-month-old mice. (Scale bar, 10 um.) (I) Grntm2.1Far/Grntm2.1Far mutant mice have increased skin lesions resulting in decreased survival. (I) Skin lesions in 16-month old mice. | ||||
| Copyright | This image is from Nguyen AD, Proc Natl Acad Sci U S A 2018 Mar 20;115(12):E2849-E2858. Copyright 2018 National Academy of Sciences, U.S.A. J:259651 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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