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| Caption | Cdc25atm1.1Hpw/Cdc25atm1.1Hpw (Cdc25A-/-) embryos undergo apoptosis during postimplantation development. (A) Whole uteri of pregnant females from heterozygous intercrosses were dissected at E7.5, then sectioned and stained with H&E (Top). The genotypes of each embryo are indicated. Adjacent sections were incubated with the terminal deoxyribonucleotide transferase and fluorescein-conjugated dUTP to label cells undergoing apoptosis (Bottom). The arrow depicts remnants of an embryo undergoing apoptosis. (Original magnification: 4X; scale bar: 200 um.) (B) Blastocysts were isolated by uterine flushing from heterozygous intercrosses at E3.5 and then cultured in vitro for 8 days. Photographs taken on days 0, 3, and 8 are shown. (Original magnification: 40X for day 0 and 10X for days 3 and 8). The photographs taken on day 3 were cropped and enlarged. (Scale bar: 100 um.) ICM, inner cell mass; TGC, trophoblast giant cell. | ||||
| Copyright | This image is from Lee G, Proc Natl Acad Sci U S A 2009 Mar 24;106(12):4701-6. Copyright 2009 National Academy of Sciences, U.S.A. J:145768 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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