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| Caption | Brain region specific and age-dependent alterations in spine density in Kalrntm1Ppen/Kalrntm1Ppen mice. (A) Golgi-stained pyramidal neurons from frontal cortex layer V in knockout (KO) and wild-type (WT) mice. (B) Quantification of (A) indicates that KO mice have a robust reduction in spine density in the frontal cortex relative to WT mice (***, P < 0.0001). (E) Two-photon imaging of layer V frontal cortical neurons in slices from 3- and 12-week-old mice. (F) Quantification of (E) shows that frontal cortex spine density was severely reduced in 12-week-old KO mice (***, P < 0.0001). | ||||
| Copyright | This image is from Cahill ME, Proc Natl Acad Sci U S A 2009 Aug 4;106(31):13058-63. Copyright 2009 National Academy of Sciences, U.S.A. J:152011 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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