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| Caption | Ataxic behavior in Trpc3Mwk/Trpc3+ (Mwk/+) mice. (A) Representative footprint patterns of wild-type (WT) and mutant mice at 2 months. Footprint patterns were quantitatively assessed for gait width (B) and step alternation uniformity (C). Mutant mice displayed significantly wider gait (33 +/- 2 mm vs. 27 +/- 1 mm) and irregular step alternation (alternation coefficient 0.36 +/- 0.035 vs. 0.24 +/- 0.02) compared with WT controls (mean +/- SEM, n = 8, P < 0.05, ANOVA followed by Fisher's PLSD post hoc test). (D) Static rod performance of WT and mutant mice at 2 months. Mutant mice were significantly impaired in their ability to walk across the beam (35.7 +/-13.25 sec vs. 180 +/- 0 sec; mean +/- SEM, n = 8, P < 0.0001, ANOVA followed by Fisher's PLSD post hoc test). | ||||
| Copyright | This image is from Becker EB, Proc Natl Acad Sci U S A 2009 Apr 21;106(16):6706-11. Copyright 2009 National Academy of Sciences, U.S.A. J:148340 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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