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| Caption | Histological analysis of Atmintm1.1Jhh/Atmintm1.1Jhh (KO) embryos. (A) Sagittal sections of comparable levels of wild-type (WT) and KO littermates at E18.5. Note the absence of lung (arrow), hypoplastic thymus (arrowhead), compressed thorax, steep ascending aorta, and exencephaly in the KO embryo. This embryo also represents an isolated case of omphalocele. Scale bars = 2 mm. (B) Micrographs of comparable sagittal sections of WT and KO littermates at E12.5-16.5. Note the apparent caudal drop of the atrium relative to the ventricle in KO embryos compared to WT littermates where the atrium seems to be propped up by the developing left lung. Scale bars = 1 mm. (C) Micrographs of comparable transverse sections of E12.5 WT and KO littermates at the upper (top panels) and lower levels (bottom panels) of the thorax. Open arrowheads point to the oesophagus, the filled arrowhead and arrows point at the trachea and lungs respectively that are only present in the WT. | ||||
| Copyright | This image is from Jurado S, PLoS Genet 2010;6(10):e1001170, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:167544 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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