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| Caption | Assessment of atherosclerosis initiation and progression in atheroprone male and female mice with or without endothelial-specific deletion of NCK2. APOE-deficient (Apoetm1Unc/Apoetm1Unc) mice were crossed with mice homozygous for both an Nck1-null allele and a floxed Nck2 allele and that carried inducible cre recombinase to selectively inactivate Nck2 in the endothelium (Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw Nck2tm3Paw/Nck2tm3Paw). Tamoxifen-induced cre recombination mediates excision of the loxP site-flanked exon 1 of Nck2. Experimental groups consisted of male and female mice with (eNck2+) and without (eNck2-) NCK2 expression in the endothelium. (E) Representative images of en face preparations of mouse thoracic aortas stained with Oil Red O. Aortas were obtained from male (left) and female (right) mice fed a high-fat diet (HFD) for 8 or 16 weeks to assess atherosclerosis initiation and progression, respectively. The scale bar represents 2 mm. (F) Box plots showing quantification of plaque burden as percentage of exposed intimal area occupied by lesions in male (left) and female (right) mice. Statistical significance was determined by two-way ANOVA followed by Tukey's multiple means comparison test. *p<0.05. Numbers of animals/group (n) are indicated in parentheses. | ||||||||||
| Copyright | This image is from the Laboratory of Dr. Gonzalo M Rivera at Texas A&M University and is displayed with the permission of the author. J:327349 | ||||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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